Behavioural and biological effects of Methamphetamine

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Assessment Task 3Due Date%ILOs Assessed
Major Essay (1500 words)Wednesday June 2,


401, 2, 3, 4
Submission Details
Note that assignment submissions for this subject are entirely online through the Assignment link provided on LMS. Do not submit a hardcopy.
Grading Criteria and Feedback
Please refer to the marking guide available on LMS .
Description of Task
Write a 1500 word essay on one of the following topics. Depth of understanding, clarity of argument and economy of expression will be rewarded. Remember, your job is to answer the essay question – do not just summarise the research papers/textbook/lectures/tutorials! And of course, be very careful to avoid academic misconduct and plagiarism.

Make sure your essay is on topic, i.e., that it really speaks to the issue you of your essay question. It is important to write a coherent argument – the opening paragraphs should tell your reader where the essay is heading, brief pointers along the way should clearly indicate what the evidence implies and how it relates to the essay question, and a concluding paragraph (or two) should make your answer to the question and position on the issue clear. Only include research evidence that is relevant to the topic, and thus builds a compelling answer to the essay question.

Evidence of having read (and understood!) at least five experimental papers (and one or more review papers/book chapters) is expected for this essay. Starting references are provided for the essay, however citing these papers is NOT a marking criterion! Make sure you base your essay on reliable academic resources (i.e., original journal articles you have read. Hint: Wikipedia is NOT a reliable academic resource!).

TOPIC 1: The behavioural and biological effects of Methamphetamine use.

Starting References:

Yui K, Ikemoto S, Ishiguro T, Goto K. Studies of amphetamine or methamphetamine psychosis in Japan: relation of methamphetamine psychosis to schizophrenia. Ann N Y Acad Sci. 2000 Sep;914:1-12. doi: 10.1111/j.1749-6632.2000.tb05178.x. PMID: 11085303.

Guerin AA, Bonomo Y, Lawrence AJ, Baune BT, Nestler EJ, Rossell SL, Kim JH. Cognition and Related Neural Findings on Methamphetamine Use Disorder: Insights and Treatment Implications From Schizophrenia Research. Front Psychiatry. 2019 Dec 17;10:880. doi: 10.3389/fpsyt.2019.00880. PMID: 31920743; PMCID: PMC6928591.

Wearne TA, Cornish JL. A Comparison of Methamphetamine-Induced Psychosis and Schizophrenia: A Review of Positive, Negative, and Cognitive Symptomatology. Front Psychiatry. 2018 Oct 10;9:491. doi: 10.3389/fpsyt.2018.00491. PMID: 30364176; PMCID: PMC6191498.

Voce A, McKetin R, Burns R, Castle D, Calabria B. The relationship between illicit amphetamine use and psychiatric symptom profiles in schizophrenia and affective psychoses. Psychiatry Res. 2018 Jul;265:19-24. doi: 10.1016/j.psychres.2018.04.015. Epub 2018 Apr 5. PMID: 29680513.

TOPIC 2: The behavioural and biological effects of PCP use.

Starting References:

Javitt, D. C., Zukin, S. R., Heresco-Levy, U., & Umbricht, D. (2012). Has an angel shown the way? Etiological and therapeutic implications of the PCP/NMDA model of schizophrenia. Schizophrenia bulletin, 38(5), 958–966.

Cadinu D, Grayson B, Podda G, Harte MK, Doostdar N, Neill JC. NMDA receptor antagonist rodent models for cognition in schizophrenia and identification of novel drug treatments, an update.

Neuropharmacology. 2018 Nov;142:41-62. doi: 10.1016/j.neuropharm.2017.11.045. Epub 2017 Nov 28.

PMID: 29196183.

Mouri A, Noda Y, Enomoto T, Nabeshima T. Phencyclidine animal models of schizophrenia: approaches from abnormality of glutamatergic neurotransmission and neurodevelopment. Neurochem Int. 2007 Jul- Sep;51(2-4):173-84. doi: 10.1016/j.neuint.2007.06.019. Epub 2007 Jun 27. PMID: 17669558.