Differences between gastric and duodenal ulcers, etiology, clinical manifestations, and treatment

Gastric and duodenal ulcers are two types of peptic ulcers that occur in the stomach and the duodenum, respectively. Although both types of ulcers are caused by similar factors, they differ in their location, clinical manifestations, and treatment.

gastric and duodenal ulcers

Gastric and duodenal ulcers

Here are the differences between these ulcers in terms of etiology, clinical manifestations, and treatment:


  • Both types of ulcers are primarily caused by an infection with the bacteria Helicobacter pylori (H. pylori) or long-term use of nonsteroidal anti-inflammatory drugs (NSAIDs) such as aspirin, ibuprofen, or naproxen. Other factors that can contribute to the development of these ulcers include smoking, excessive alcohol consumption, stress, and genetic predisposition.
  • Gastric ulcers are more commonly associated with H. pylori infection, while NSAID use is the most common cause of duodenal ulcers.

Clinical Manifestations:

  • The symptoms of these ulcers can be similar, but there are some differences in the way they manifest. Gastric ulcers tend to cause pain in the upper abdomen that worsens after eating, whereas duodenal ulcers tend to cause pain that improves after eating or taking antacids.
  • Other common symptoms of duodenal and gastric ulcers include nausea, vomiting, bloating, weight loss, and loss of appetite. In severe cases, bleeding can occur, leading to black, tarry stools or vomiting of blood.


  • Treatment for both types of ulcers involves a combination of antibiotics to eradicate H. pylori infection, and proton pump inhibitors (PPIs) to reduce stomach acid production.
  • In cases where NSAID use is the primary cause of the ulcer, stopping or reducing the use of these drugs is necessary.
  • Surgery is rarely required, but it may be necessary if the ulcer is not responding to medical treatment, or if there is severe bleeding or perforation.
  • Additionally, lifestyle modifications such as quitting smoking, limiting alcohol consumption, and managing stress can also help to prevent and treat ulcers.

In summary, although both types of ulcers share some common causes and symptoms, they differ in their location, clinical manifestations, and treatment. A proper diagnosis is essential to determine the most effective treatment plan.